DHEA-S (Dehydroepiandrosterone Sulfate)

WHAT IS DHEA?

DHEA-S (Dehydroepiandrosterone sulfate), a vital sex hormone, plays a crucial role in supporting a healthy libido, boosting energy, and strengthening the immune system by acting as a natural counterbalance to stress hormones like cortisol. Having an adequate level of DHEA-S is associated with improved heart health, reduced abdominal fat, a well-functioning metabolism, enhanced mood, memory, and quality of sleep.

It contributes to the development of specific male traits during puberty and can be converted into testosterone and more potent androgens or transformed into a female hormone (estrogen). DHEA-S is primarily produced by the adrenal cortex, the outer layer of the adrenal glands, with smaller amounts produced in the testes and ovaries. Its secretion is regulated by the pituitary hormone adrenocorticotropic hormone (ACTH) and other pituitary factors, making it a strong marker for adrenal function. Conditions like cancers, adrenal tumors, and hyperplasia can lead to excessive DHEA sulfate production. While elevated DHEA-S levels might not be easily detected in adult men, they can manifest as visible symptoms of virilization and amenorrhea.

WHAT IS THE PURPOSE OF THIS TEST?

Order the DHEA-S Blood Test to assess adrenal function and pinpoint the root cause of excess androgen production leading to issues like virilization, infertility, hirsutism, or amenorrhea. This test helps:

1. Assess the proper functioning of the adrenal glands.
2. Determine if DHEAS-secreting conditions originate in the testicles or ovaries (ovarian tumors).
3. Diagnose tumors in the adrenal cortex, which could be indicative of adrenal cancers.
4. Aid in diagnosing adrenogenital syndrome and adrenal gland enlargement (hyperplasia) in adults.

WHEN SHOULD I ORDER THIS TEST?

If you've experienced symptoms linked to excess male hormones (virilization) or if your healthcare provider needs to assess your adrenal gland function, you can order this test.

Common signs of virilization may include:

• No or irregular menstrual periods
• Infertility
• Deeper voice
• Excessive facial or body hair (hirsutism)
• Male pattern baldness
• Increased muscle mass
• Acne
• Enlarged Adam's apple
• Reduced breast size
• Ambiguous genitalia
• Early puberty in young boys

Conditions related to adrenal gland issues may include:

• Adrenogenital syndrome
• Adrenal gland tumors
• Polycystic ovary syndrome (PCOS)
• Abdominal pain
• Obesity
• Diabetes
• High blood pressure
• Muscle and bone weakness
• Mood swings, irritability, or depression